PlantImRecepV1, Main, Exploration, bibRecord, 000122

Ligand-induced monoubiquitination of BIK1 regulates plant immunity.

Identifieur interne : 000122 ( Main/Exploration ); précédent : 000121; suivant : 000123

Ligand-induced monoubiquitination of BIK1 regulates plant immunity.

Auteurs : Xiyu Ma [États-Unis] ; Lucas A N. Claus [Belgique] ; Michelle E. Leslie [États-Unis] ; Kai Tao [États-Unis] ; Zhiping Wu [États-Unis] ; Jun Liu [États-Unis] ; Xiao Yu [États-Unis] ; Bo Li [États-Unis] ; Jinggeng Zhou [États-Unis] ; Daniel V. Savatin [Belgique] ; Junmin Peng [États-Unis] ; Brett M. Tyler [États-Unis] ; Antje Heese [États-Unis] ; Eugenia Russinova [Belgique] ; Ping He [États-Unis] ; Libo Shan [États-Unis]

Source :

Nature [ 1476-4687 ] ; 2020.

RBID : pubmed:32404997

Descripteurs français

English descriptors

KwdEn :
- Arabidopsis (enzymology), Arabidopsis (immunology), Arabidopsis (metabolism), Arabidopsis Proteins (chemistry), Arabidopsis Proteins (metabolism), Endocytosis (MeSH), Ligands (MeSH), Pathogen-Associated Molecular Pattern Molecules (immunology), Phosphorylation (MeSH), Plant Immunity (immunology), Protein Kinases (metabolism), Protein-Serine-Threonine Kinases (chemistry), Protein-Serine-Threonine Kinases (metabolism), Receptors, Pattern Recognition (immunology), Ubiquitin-Protein Ligases (chemistry), Ubiquitin-Protein Ligases (metabolism), Ubiquitination (MeSH).
MESH :
- chemical , chemistry : Arabidopsis Proteins, Protein-Serine-Threonine Kinases, Ubiquitin-Protein Ligases.
- enzymology : Arabidopsis.
- immunology : Arabidopsis, Pathogen-Associated Molecular Pattern Molecules, Plant Immunity, Receptors, Pattern Recognition.
- metabolism : Arabidopsis, Arabidopsis Proteins, Protein Kinases, Protein-Serine-Threonine Kinases, Ubiquitin-Protein Ligases.
- Endocytosis, Ligands, Phosphorylation, Ubiquitination.

Abstract

Recognition of microbe-associated molecular patterns (MAMPs) by pattern recognition receptors (PRRs) triggers the first line of inducible defence against invading pathogens^1-3. Receptor-like cytoplasmic kinases (RLCKs) are convergent regulators that associate with multiple PRRs in plants⁴. The mechanisms that underlie the activation of RLCKs are unclear. Here we show that when MAMPs are detected, the RLCK BOTRYTIS-INDUCED KINASE 1 (BIK1) is monoubiquitinated following phosphorylation, then released from the flagellin receptor FLAGELLIN SENSING 2 (FLS2)-BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) complex, and internalized dynamically into endocytic compartments. The Arabidopsis E3 ubiquitin ligases RING-H2 FINGER A3A (RHA3A) and RHA3B mediate the monoubiquitination of BIK1, which is essential for the subsequent release of BIK1 from the FLS2-BAK1 complex and activation of immune signalling. Ligand-induced monoubiquitination and endosomal puncta of BIK1 exhibit spatial and temporal dynamics that are distinct from those of the PRR FLS2. Our study reveals the intertwined regulation of PRR-RLCK complex activation by protein phosphorylation and ubiquitination, and shows that ligand-induced monoubiquitination contributes to the release of BIK1 family RLCKs from the PRR complex and activation of PRR signalling.

DOI: 10.1038/s41586-020-2210-3
PubMed: 32404997
PubMed Central: PMC7233372

Affiliations:

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Le document en format XML

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<author><name sortKey="Zhou, Jinggeng" sort="Zhou, Jinggeng" uniqKey="Zhou J" first="Jinggeng" last="Zhou">Jinggeng Zhou</name>
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<author><name sortKey="Peng, Junmin" sort="Peng, Junmin" uniqKey="Peng J" first="Junmin" last="Peng">Junmin Peng</name>
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<author><name sortKey="Russinova, Eugenia" sort="Russinova, Eugenia" uniqKey="Russinova E" first="Eugenia" last="Russinova">Eugenia Russinova</name>
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<author><name sortKey="He, Ping" sort="He, Ping" uniqKey="He P" first="Ping" last="He">Ping He</name>
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<author><name sortKey="Shan, Libo" sort="Shan, Libo" uniqKey="Shan L" first="Libo" last="Shan">Libo Shan</name>
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<affiliation wicri:level="2"><nlm:affiliation>Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX, USA. lshan@tamu.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX</wicri:regionArea>
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<author><name sortKey="Tao, Kai" sort="Tao, Kai" uniqKey="Tao K" first="Kai" last="Tao">Kai Tao</name>
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<author><name sortKey="Wu, Zhiping" sort="Wu, Zhiping" uniqKey="Wu Z" first="Zhiping" last="Wu">Zhiping Wu</name>
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<placeName><region type="state">Tennessee</region>
</placeName>
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<author><name sortKey="Liu, Jun" sort="Liu, Jun" uniqKey="Liu J" first="Jun" last="Liu">Jun Liu</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX</wicri:regionArea>
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<author><name sortKey="Yu, Xiao" sort="Yu, Xiao" uniqKey="Yu X" first="Xiao" last="Yu">Xiao Yu</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Li, Bo" sort="Li, Bo" uniqKey="Li B" first="Bo" last="Li">Bo Li</name>
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<country xml:lang="fr">États-Unis</country>
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</placeName>
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<affiliation wicri:level="2"><nlm:affiliation>Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX, USA.</nlm:affiliation>
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<wicri:regionArea>Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX</wicri:regionArea>
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</placeName>
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<author><name sortKey="Zhou, Jinggeng" sort="Zhou, Jinggeng" uniqKey="Zhou J" first="Jinggeng" last="Zhou">Jinggeng Zhou</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX, USA.</nlm:affiliation>
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<affiliation wicri:level="4"><nlm:affiliation>Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent</wicri:regionArea>
<orgName type="university">Université de Gand</orgName>
<placeName><settlement type="city">Gand</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province de Flandre-Orientale</region>
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<affiliation wicri:level="1"><nlm:affiliation>Center for Plant Systems Biology, VIB, Ghent, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
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<author><name sortKey="Peng, Junmin" sort="Peng, Junmin" uniqKey="Peng J" first="Junmin" last="Peng">Junmin Peng</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Structural Biology, Center for Proteomics and Metabolomics, St Jude Children's Research Hospital, Memphis, TN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Structural Biology, Center for Proteomics and Metabolomics, St Jude Children's Research Hospital, Memphis, TN</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Department of Developmental Neurobiology, Center for Proteomics and Metabolomics, St Jude Children's Research Hospital, Memphis, TN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Developmental Neurobiology, Center for Proteomics and Metabolomics, St Jude Children's Research Hospital, Memphis, TN</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
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<author><name sortKey="Tyler, Brett M" sort="Tyler, Brett M" uniqKey="Tyler B" first="Brett M" last="Tyler">Brett M. Tyler</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Genome Research and Biocomputing and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR</wicri:regionArea>
<placeName><region type="state">Oregon</region>
</placeName>
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</author>
<author><name sortKey="Heese, Antje" sort="Heese, Antje" uniqKey="Heese A" first="Antje" last="Heese">Antje Heese</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry, Interdisciplinary Plant Group, University of Missouri-Columbia, Columbia, MO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, Interdisciplinary Plant Group, University of Missouri-Columbia, Columbia, MO</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
</placeName>
</affiliation>
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<author><name sortKey="Russinova, Eugenia" sort="Russinova, Eugenia" uniqKey="Russinova E" first="Eugenia" last="Russinova">Eugenia Russinova</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent</wicri:regionArea>
<orgName type="university">Université de Gand</orgName>
<placeName><settlement type="city">Gand</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province de Flandre-Orientale</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Center for Plant Systems Biology, VIB, Ghent, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Center for Plant Systems Biology, VIB, Ghent</wicri:regionArea>
<wicri:noRegion>Ghent</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="He, Ping" sort="He, Ping" uniqKey="He P" first="Ping" last="He">Ping He</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA. pinghe@tamu.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX</wicri:regionArea>
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</placeName>
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<affiliation wicri:level="2"><nlm:affiliation>Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX, USA. pinghe@tamu.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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</placeName>
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<author><name sortKey="Shan, Libo" sort="Shan, Libo" uniqKey="Shan L" first="Libo" last="Shan">Libo Shan</name>
<affiliation wicri:level="2"><nlm:affiliation>Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX, USA. lshan@tamu.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX, USA. lshan@tamu.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
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<series><title level="j">Nature</title>
<idno type="eISSN">1476-4687</idno>
<imprint><date when="2020" type="published">2020</date>
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<term>Arabidopsis (immunology)</term>
<term>Arabidopsis (metabolism)</term>
<term>Arabidopsis Proteins (chemistry)</term>
<term>Arabidopsis Proteins (metabolism)</term>
<term>Endocytosis (MeSH)</term>
<term>Ligands (MeSH)</term>
<term>Pathogen-Associated Molecular Pattern Molecules (immunology)</term>
<term>Phosphorylation (MeSH)</term>
<term>Plant Immunity (immunology)</term>
<term>Protein Kinases (metabolism)</term>
<term>Protein-Serine-Threonine Kinases (chemistry)</term>
<term>Protein-Serine-Threonine Kinases (metabolism)</term>
<term>Receptors, Pattern Recognition (immunology)</term>
<term>Ubiquitin-Protein Ligases (chemistry)</term>
<term>Ubiquitin-Protein Ligases (metabolism)</term>
<term>Ubiquitination (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Arabidopsis (enzymologie)</term>
<term>Arabidopsis (immunologie)</term>
<term>Arabidopsis (métabolisme)</term>
<term>Endocytose (MeSH)</term>
<term>Immunité des plantes (immunologie)</term>
<term>Ligands (MeSH)</term>
<term>Molécules contenant des motifs associés aux pathogènes (immunologie)</term>
<term>Phosphorylation (MeSH)</term>
<term>Protein kinases (métabolisme)</term>
<term>Protein-Serine-Threonine Kinases (composition chimique)</term>
<term>Protein-Serine-Threonine Kinases (métabolisme)</term>
<term>Protéines d'Arabidopsis (composition chimique)</term>
<term>Protéines d'Arabidopsis (métabolisme)</term>
<term>Récepteurs de reconnaissance de motifs moléculaires (immunologie)</term>
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<term>Ubiquitin-protein ligases (métabolisme)</term>
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<term>Protéines d'Arabidopsis</term>
<term>Ubiquitin-protein ligases</term>
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<term>Immunité des plantes</term>
<term>Molécules contenant des motifs associés aux pathogènes</term>
<term>Récepteurs de reconnaissance de motifs moléculaires</term>
</keywords>
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<term>Pathogen-Associated Molecular Pattern Molecules</term>
<term>Plant Immunity</term>
<term>Receptors, Pattern Recognition</term>
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<front><div type="abstract" xml:lang="en">Recognition of microbe-associated molecular patterns (MAMPs) by pattern recognition receptors (PRRs) triggers the first line of inducible defence against invading pathogens<sup>1-3</sup>
. Receptor-like cytoplasmic kinases (RLCKs) are convergent regulators that associate with multiple PRRs in plants<sup>4</sup>
. The mechanisms that underlie the activation of RLCKs are unclear. Here we show that when MAMPs are detected, the RLCK BOTRYTIS-INDUCED KINASE 1 (BIK1) is monoubiquitinated following phosphorylation, then released from the flagellin receptor FLAGELLIN SENSING 2 (FLS2)-BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) complex, and internalized dynamically into endocytic compartments. The Arabidopsis E3 ubiquitin ligases RING-H2 FINGER A3A (RHA3A) and RHA3B mediate the monoubiquitination of BIK1, which is essential for the subsequent release of BIK1 from the FLS2-BAK1 complex and activation of immune signalling. Ligand-induced monoubiquitination and endosomal puncta of BIK1 exhibit spatial and temporal dynamics that are distinct from those of the PRR FLS2. Our study reveals the intertwined regulation of PRR-RLCK complex activation by protein phosphorylation and ubiquitination, and shows that ligand-induced monoubiquitination contributes to the release of BIK1 family RLCKs from the PRR complex and activation of PRR signalling.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32404997</PMID>
<DateCompleted><Year>2020</Year>
<Month>06</Month>
<Day>15</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>10</Month>
<Day>23</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-4687</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>581</Volume>
<Issue>7807</Issue>
<PubDate><Year>2020</Year>
<Month>05</Month>
</PubDate>
</JournalIssue>
<Title>Nature</Title>
<ISOAbbreviation>Nature</ISOAbbreviation>
</Journal>
<ArticleTitle>Ligand-induced monoubiquitination of BIK1 regulates plant immunity.</ArticleTitle>
<Pagination><MedlinePgn>199-203</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/s41586-020-2210-3</ELocationID>
<Abstract><AbstractText>Recognition of microbe-associated molecular patterns (MAMPs) by pattern recognition receptors (PRRs) triggers the first line of inducible defence against invading pathogens<sup>1-3</sup>
. Receptor-like cytoplasmic kinases (RLCKs) are convergent regulators that associate with multiple PRRs in plants<sup>4</sup>
. The mechanisms that underlie the activation of RLCKs are unclear. Here we show that when MAMPs are detected, the RLCK BOTRYTIS-INDUCED KINASE 1 (BIK1) is monoubiquitinated following phosphorylation, then released from the flagellin receptor FLAGELLIN SENSING 2 (FLS2)-BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) complex, and internalized dynamically into endocytic compartments. The Arabidopsis E3 ubiquitin ligases RING-H2 FINGER A3A (RHA3A) and RHA3B mediate the monoubiquitination of BIK1, which is essential for the subsequent release of BIK1 from the FLS2-BAK1 complex and activation of immune signalling. Ligand-induced monoubiquitination and endosomal puncta of BIK1 exhibit spatial and temporal dynamics that are distinct from those of the PRR FLS2. Our study reveals the intertwined regulation of PRR-RLCK complex activation by protein phosphorylation and ubiquitination, and shows that ligand-induced monoubiquitination contributes to the release of BIK1 family RLCKs from the PRR complex and activation of PRR signalling.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ma</LastName>
<ForeName>Xiyu</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Claus</LastName>
<ForeName>Lucas A N</ForeName>
<Initials>LAN</Initials>
<AffiliationInfo><Affiliation>Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Plant Systems Biology, VIB, Ghent, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leslie</LastName>
<ForeName>Michelle E</ForeName>
<Initials>ME</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, Interdisciplinary Plant Group, University of Missouri-Columbia, Columbia, MO, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Elemental Enzymes, St Louis, MO, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tao</LastName>
<ForeName>Kai</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Center for Genome Research and Biocomputing and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Zhiping</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Department of Structural Biology, Center for Proteomics and Metabolomics, St Jude Children's Research Hospital, Memphis, TN, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Developmental Neurobiology, Center for Proteomics and Metabolomics, St Jude Children's Research Hospital, Memphis, TN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Jun</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Xiao</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Bo</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Jinggeng</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Savatin</LastName>
<ForeName>Daniel V</ForeName>
<Initials>DV</Initials>
<AffiliationInfo><Affiliation>Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Plant Systems Biology, VIB, Ghent, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Peng</LastName>
<ForeName>Junmin</ForeName>
<Initials>J</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-0472-7648</Identifier>
<AffiliationInfo><Affiliation>Department of Structural Biology, Center for Proteomics and Metabolomics, St Jude Children's Research Hospital, Memphis, TN, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Developmental Neurobiology, Center for Proteomics and Metabolomics, St Jude Children's Research Hospital, Memphis, TN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tyler</LastName>
<ForeName>Brett M</ForeName>
<Initials>BM</Initials>
<AffiliationInfo><Affiliation>Center for Genome Research and Biocomputing and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Heese</LastName>
<ForeName>Antje</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, Interdisciplinary Plant Group, University of Missouri-Columbia, Columbia, MO, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Russinova</LastName>
<ForeName>Eugenia</ForeName>
<Initials>E</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-0569-1977</Identifier>
<AffiliationInfo><Affiliation>Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Plant Systems Biology, VIB, Ghent, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>He</LastName>
<ForeName>Ping</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA. pinghe@tamu.edu.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX, USA. pinghe@tamu.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shan</LastName>
<ForeName>Libo</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX, USA. lshan@tamu.edu.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX, USA. lshan@tamu.edu.</Affiliation>
</AffiliationInfo>
</Author>
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<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
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<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
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<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
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<Month>04</Month>
<Day>22</Day>
</ArticleDate>
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<MedlineTA>Nature</MedlineTA>
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<NameOfSubstance UI="C509522">BIK1 protein, Arabidopsis</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D017346">Protein-Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D017360" MajorTopicYN="N">Arabidopsis</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D029681" MajorTopicYN="N">Arabidopsis Proteins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004705" MajorTopicYN="N">Endocytosis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008024" MajorTopicYN="N">Ligands</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000069452" MajorTopicYN="N">Pathogen-Associated Molecular Pattern Molecules</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057865" MajorTopicYN="N">Plant Immunity</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011494" MajorTopicYN="N">Protein Kinases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017346" MajorTopicYN="N">Protein-Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051192" MajorTopicYN="N">Receptors, Pattern Recognition</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D044767" MajorTopicYN="N">Ubiquitin-Protein Ligases</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054875" MajorTopicYN="Y">Ubiquitination</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>09</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>02</Month>
<Day>21</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>5</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>5</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>6</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32404997</ArticleId>
<ArticleId IdType="doi">10.1038/s41586-020-2210-3</ArticleId>
<ArticleId IdType="pii">10.1038/s41586-020-2210-3</ArticleId>
<ArticleId IdType="pmc">PMC7233372</ArticleId>
<ArticleId IdType="mid">NIHMS1565517</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Belgique</li>
<li>États-Unis</li>
</country>
<region><li>Missouri (État)</li>
<li>Oregon</li>
<li>Province de Flandre-Orientale</li>
<li>Région flamande</li>
<li>Tennessee</li>
<li>Texas</li>
</region>
<settlement><li>Gand</li>
</settlement>
<orgName><li>Université de Gand</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Texas"><name sortKey="Ma, Xiyu" sort="Ma, Xiyu" uniqKey="Ma X" first="Xiyu" last="Ma">Xiyu Ma</name>
</region>
<name sortKey="He, Ping" sort="He, Ping" uniqKey="He P" first="Ping" last="He">Ping He</name>
<name sortKey="He, Ping" sort="He, Ping" uniqKey="He P" first="Ping" last="He">Ping He</name>
<name sortKey="Heese, Antje" sort="Heese, Antje" uniqKey="Heese A" first="Antje" last="Heese">Antje Heese</name>
<name sortKey="Leslie, Michelle E" sort="Leslie, Michelle E" uniqKey="Leslie M" first="Michelle E" last="Leslie">Michelle E. Leslie</name>
<name sortKey="Leslie, Michelle E" sort="Leslie, Michelle E" uniqKey="Leslie M" first="Michelle E" last="Leslie">Michelle E. Leslie</name>
<name sortKey="Li, Bo" sort="Li, Bo" uniqKey="Li B" first="Bo" last="Li">Bo Li</name>
<name sortKey="Li, Bo" sort="Li, Bo" uniqKey="Li B" first="Bo" last="Li">Bo Li</name>
<name sortKey="Liu, Jun" sort="Liu, Jun" uniqKey="Liu J" first="Jun" last="Liu">Jun Liu</name>
<name sortKey="Liu, Jun" sort="Liu, Jun" uniqKey="Liu J" first="Jun" last="Liu">Jun Liu</name>
<name sortKey="Ma, Xiyu" sort="Ma, Xiyu" uniqKey="Ma X" first="Xiyu" last="Ma">Xiyu Ma</name>
<name sortKey="Peng, Junmin" sort="Peng, Junmin" uniqKey="Peng J" first="Junmin" last="Peng">Junmin Peng</name>
<name sortKey="Peng, Junmin" sort="Peng, Junmin" uniqKey="Peng J" first="Junmin" last="Peng">Junmin Peng</name>
<name sortKey="Shan, Libo" sort="Shan, Libo" uniqKey="Shan L" first="Libo" last="Shan">Libo Shan</name>
<name sortKey="Shan, Libo" sort="Shan, Libo" uniqKey="Shan L" first="Libo" last="Shan">Libo Shan</name>
<name sortKey="Tao, Kai" sort="Tao, Kai" uniqKey="Tao K" first="Kai" last="Tao">Kai Tao</name>
<name sortKey="Tyler, Brett M" sort="Tyler, Brett M" uniqKey="Tyler B" first="Brett M" last="Tyler">Brett M. Tyler</name>
<name sortKey="Wu, Zhiping" sort="Wu, Zhiping" uniqKey="Wu Z" first="Zhiping" last="Wu">Zhiping Wu</name>
<name sortKey="Wu, Zhiping" sort="Wu, Zhiping" uniqKey="Wu Z" first="Zhiping" last="Wu">Zhiping Wu</name>
<name sortKey="Yu, Xiao" sort="Yu, Xiao" uniqKey="Yu X" first="Xiao" last="Yu">Xiao Yu</name>
<name sortKey="Yu, Xiao" sort="Yu, Xiao" uniqKey="Yu X" first="Xiao" last="Yu">Xiao Yu</name>
<name sortKey="Zhou, Jinggeng" sort="Zhou, Jinggeng" uniqKey="Zhou J" first="Jinggeng" last="Zhou">Jinggeng Zhou</name>
<name sortKey="Zhou, Jinggeng" sort="Zhou, Jinggeng" uniqKey="Zhou J" first="Jinggeng" last="Zhou">Jinggeng Zhou</name>
</country>
<country name="Belgique"><region name="Région flamande"><name sortKey="Claus, Lucas A N" sort="Claus, Lucas A N" uniqKey="Claus L" first="Lucas A N" last="Claus">Lucas A N. Claus</name>
</region>
<name sortKey="Claus, Lucas A N" sort="Claus, Lucas A N" uniqKey="Claus L" first="Lucas A N" last="Claus">Lucas A N. Claus</name>
<name sortKey="Russinova, Eugenia" sort="Russinova, Eugenia" uniqKey="Russinova E" first="Eugenia" last="Russinova">Eugenia Russinova</name>
<name sortKey="Russinova, Eugenia" sort="Russinova, Eugenia" uniqKey="Russinova E" first="Eugenia" last="Russinova">Eugenia Russinova</name>
<name sortKey="Savatin, Daniel V" sort="Savatin, Daniel V" uniqKey="Savatin D" first="Daniel V" last="Savatin">Daniel V. Savatin</name>
<name sortKey="Savatin, Daniel V" sort="Savatin, Daniel V" uniqKey="Savatin D" first="Daniel V" last="Savatin">Daniel V. Savatin</name>
</country>
</tree>
</affiliations>
</record>

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	Serveur d'exploration sur les récepteurs immunitaires végétaux
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Serveur d'exploration sur les récepteurs immunitaires végétaux

Ligand-induced monoubiquitination of BIK1 regulates plant immunity.

Ligand-induced monoubiquitination of BIK1 regulates plant immunity.

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